Hi, Yes!!! I'm using the Griffin g4port with the two (2) OS X drivers that you must download and install....they are 1- g4port OS X driver 2- g4port OS X midi setup driver My Midi rig uses a MOTU MTP AV (serial) that feeds 30 pieces of midi gear (keys /modules/ multi FX & sync boxes) and thus far it all works. I made an exact replica of my OMS studio setup so that all my PT 5 sessions will playback exactly as I initially recorded them, when loaded into PT 6. Also... GeeThree offers two similar drivers for their Stealth Port, I haven't tried them yet, but when I do, I'll Post post my results.